Search results for "Tricarboxylic acid cycle metabolites"

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Glycolysis/gluconeogenesis- and tricarboxylic acid cycle–related metabolites, Mediterranean diet, and type 2 diabetes

2020

Background: Glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle metabolites have been associated with type 2 diabetes (T2D). However, the associations of these metabolites with T2D incidence and the potential effect of dietary interventions remain unclear. Objectives: We aimed to evaluate the association of baseline and 1-y changes in glycolysis/gluconeogenesis and TCA cycle metabolites with insulin resistance and T2D incidence, and the potential modifying effect of Mediterranean diet (MedDiet) interventions. Methods: We included 251 incident T2D cases and 638 noncases in a nested case-cohort study within the PREDIMED Study during median follow-up of 3.8 y. Participants were alloc…

0301 basic medicineMalemedicine.medical_specialtyMediterranean dietPopulationCitric Acid CycleMedicine (miscellaneous)030209 endocrinology & metabolismType 2 diabetesDiet MediterraneanCohort Studies03 medical and health sciences0302 clinical medicineInsulin resistanceInternal medicineMetabolomicsMedicineHumansGlycolysiseducationAgedAged 80 and overeducation.field_of_studyNutrition and Dieteticsbusiness.industryGlycolysis metabolitesGluconeogenesisInsulin resistanceType 2 diabetesTricarboxylic acid cycle metabolitesMiddle Agedmedicine.diseaseCitric acid cycleOriginal Research Communications030104 developmental biologyEndocrinologyGluconeogenesisDiabetes Mellitus Type 2Relative riskCase-Control StudiesFemalebusinessGlycolysis

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